Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy

STATUS

Recruiting
End date

Jun 5, 2026
participants needed

30
sponsor

Oregon Health and Science University

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Updated on 19 February 2024

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transcranial magnetic stimulation

dopamine

progressive supranuclear palsy

speech therapy

Summary

The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP by increasing functional connectivity between the cerebellum, thalamus, and primary motor cortex.

Details

Condition	Progressive supranuclear palsy, Palsy Supranuclear
Age	40years - 85years
Treatment	Repetitive transcranial magnetic stimulation (rTMS)
Clinical Study Identifier	NCT04468932
Sponsor	Oregon Health and Science University
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)
	age 40-85 at time of screening
	ability to understand and cooperate with simple instructions in English
	ability to read at 6th grade reading level in English
	ability to tolerate balance testing with a safety harness
	ability to refrain from other physical and speech therapy programs for the duration for the study
	ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative or NMDA receptor antagonists for the duration of the study
	females of child-bearing age must perform a urine pregnancy test and be on reliable birth control during the course of the study
Exclusion Criteria
	other significant neurological or vestibular disorders
	presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body

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Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy