Illusory Movements in Patients With Burns
-
- STATUS
- Recruiting
-
- participants needed
- 20
-
- sponsor
- Charles University, Czech Republic
Summary
Background. Large
Tested hypotheses. 1. The use of illusory movements is suitable for the rehabilitation of
patients with
Method. Pragmatic crossover study. Twenty patients with
Description
The goal of this project is to find out whether illusory movements are suitable for patients
in the early phase of
We are going to test these hypotheses:
- The use of illusory movements is suitable for patients with
burns of 20 % TBSA and more in the early acute phase of theburn disease. - The use of illusory movements reduces the extent of muscle catabolism in patients with
large
burns .
Way of solution This is a pragmatic cross-over study in patients with
The study will start after patient's basic cardiopulmonary stabilization, which usually
corresponds to days 3-5 after the
Group A: Early illusory movements Phase 1: A patient enrolled in group A will have standard rehabilitation according to the instructions of the attending surgeon and performed by an independent physiotherapist from the start of the study (Day 1), and also FPS performed by a study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of standard rehabilitation, for 14 days (Day 15).
Phase 2: From Day 16 onwards, the patient will undergo standard rehabilitation only according to the instructions of the attending surgeon and performed by an independent physiotherapist for 14 days (Day 30).
Group B: Deferred illusory movements Phase 1: A patient enrolled in group B will have standard rehabilitation according to the instructions of the attending surgeon and performed by an independent physiotherapist, from the start of the study (Day 1) for 14 days (Day 15).
Phase 2: Then, from Day 16 onwards, in addition to standard
Group C: Illusory movements in healthy individuals This group will consist of 10 healthy volunteers in whom REE will be measured before and after 30 minutes of FPS.
c) Medical, social and economic rationale of this study Large
In addition, if the positive effects of illusory movements are proved, there are many
d) Methodology Nutrition support will be provided in accordance with European Society of
Parenteral and
During the study, the following parameters will be measured, and the following examinations will be performed in addition to standard biochemical, haematological and imaging examinations of Group A and B:
- Daily
-
- Nitrogen balance;
- Resting Energy Expenditure using
indirect calorimetry ;
On Days 1, 15 and 30:
- Patient weight;
- APACHE II score;
Muscle biopsy (from m. vastus lateralis);- BMR;
Glucose disposal using a hyperinsulinaemic euglycaemic clamp;- Degree of
insulin resistance according to Homeostasis Model Assessment; - Muscle mitochondrial respiratory capacity and coupling with the Oxygraph-2K;
- Mitochondrial mass determination and dynamics in myocytes with MitoTracker ;
- Plasmatic levels of myokinins ;
- Ultrasound measurement of the rectus femoris diameter measured by an independent sonographer.
Details
Condition |
Trauma, wounds, Illusion, |
---|---|
Age | 18years - 100years |
Treatment | Functional Proprioceptive Stimulation |
Clinical Study Identifier | NCT04467619 |
Sponsor | Charles University, Czech Republic |
Last Modified on | 19 February 2024 |
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Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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