Enzalutamide Treatment in COVID-19

STATUS

Recruiting
participants needed

500
sponsor

Andreas Josefsson

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Updated on 19 February 2024

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covid-19

enzalutamide

oral contraceptives

Summary

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COVID-19 is a disease with high rate of morbidity if symptomatic. There is a great need of treatments to decrease the severity. The vast majority of patients needing intensive care are men, and this may be due to the androgens, either by regulation of TMPRSS2, necessary for virus internalization, or other mechanisms. Enzalutamide is an antiandrogen inhibiting the expression of androgen regulated proteins, such as TMPRSS2. The aim of this trial is to evaluate a possible beneficial effect of short-term enzalutamide treatment of COVID-19 patients.

Details

Condition	Corona Virus Infection, Covid 19
Age	50years - 100years
Treatment	Enzalutamide Pill
Clinical Study Identifier	NCT04475601
Sponsor	Andreas Josefsson
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Positive COVID-19 test
	Mild to severe symptoms of COVID-19
	Hospitalization
	WHO performance status 0-3
	Age above or equal to 50 years
	Can understand all the requirements of the study, provide informed consent, and provide authorization of use and disclosure of personal health information
	Estimated expected survival of 1 year (excluding symptoms due to COVID-19)
Exclusion Criteria
	Severe allergy to Enzalutamide
	Pregnant or breast-feeding women
	Need of immediate mechanical ventilation
	Current medication includes enzalutamide treatment
	Stroke or Transitory Ischemic attack in medical history
	Treatment for HIV
	Treatment with tamoxifen
	Treatment with immunosuppressive agents
	Severe immunosuppressive disease
	Treatment with warfarin or NOAC (Non-vitamin K-antagonist anticoagulants)
	Previous seizure in medical history
	Other serious illness or medical condition
	Unstable cardiovascular disease

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Enzalutamide Treatment in COVID-19