Immunotherapy in Lung Cancer: Treatment After IO Cessation.

  • STATUS
    Recruiting
  • End date
    Jun 5, 2025
  • participants needed
    300
  • sponsor
    European Lung Cancer Working Party
Updated on 19 February 2024
cancer
lung cancer
non-melanoma skin cancer
chemoradiotherapy
carcinoma
immunomodulators
stage iv non-small cell lung cancer
stage iii non-small cell lung cancer
carcinoma in situ
salvage therapy
carcinoma of the cervix
adjuvant
melanoma
small cell lung cancer

Summary

Immunotherapy is now a standard of care for first-line and eventually salvage therapy in patients with stage IV NSCLC and as adjuvant after RT-CT for stage III NSCLC.

The aim of the study is determining the therapeutic landscape and the reason for immunotherapy cessation.

Description

Patients with stage IV or unresectable not irradiable stage III NSCLC will be registered at the time receiving immunotherapy alone or in combination with chemotherapy.

When IO is stopped, reason for cessation and further treatment will be recorded.

Secondary endpoints are survival after IO cessation, activity of first salvage therapy, disease-free survival after IO cessation in patients receiving no further treatment.

Patients will be centrally registered at the ELCWP headquarter (Institut Jules Bordet, Brussels, Belgium).

Details
Condition Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Immunotherapy
Age 18years - 100years
Treatment (chemo)immunotherapy
Clinical Study IdentifierNCT04465942
SponsorEuropean Lung Cancer Working Party
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Histological diagnosis of non-small cell lung cancer (NSCLC)
Stage IVA/IVB and unresectable and non irradiable stage III NSCLC nave of immunotherapy
Patients who receive immunotherapy (any type) monotherapy, combined immunotherapy or in combination with chemotherapy for first or second-line treatment
Availability for participating in the detailed follow-up of the protocol
Signed informed consent

Exclusion Criteria

Patients receiving adjuvant immunotherapy for stage I-III NSCLC are not eligible
Tumours for which TNM stage at time of study inclusion cannot be assessed
History of prior malignant tumour, except non-melanoma skin cancer or in situ carcinoma of the cervix or of the bladder or cured malignant tumor (more than 5-year disease free interval)
Any type of immunotherapy for previous cancer
Clear my responses

How to participate?

Step 1 Connect with a study center
Entire World
Results (5 sites found)
  • 1

    Department of Intensive Care Unit and Thoracic Oncology Institut Jules Bordet

    Belgium

  • 2

    Department of Pneumology CHU Charleroi

    Belgium

  • 3

    Department of Pneumology H pital Saint-Joseph

    Belgium

  • 4

    H pital Ambroise Par

    Belgium

  • 5

    H pital Mont-Godinne

    Belgium

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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