Clinical Study of an Dendritic and Glioma Cells Fusion Vaccine With IL-12 for Treatment-na ve GBM Patients.
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- STATUS
- Recruiting
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- participants needed
- 10
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- sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
Summary
A multi-center, open-label, single-arm, phase I/II clinical study is designed to test the safety and immunogenicity of an investigational Dendritic and Glioma Cells Fusion vaccine given with IL-12 for treatment-nave patients after resection of glioblastoma.
Description
This clinical trail includes two phases: basic treatment phase and immunotherapy phase. In basic treatment phase, patients will receive concomitant radiation and TMZ-chemotherapy. In immunotherapy phase, besides maintenance chemotherapy with TMZ, Fusion cells will be administered with IL-12 to enhance the immunity of patients.
Details
| Condition | Neuroectodermal Tumor, neurectoderma, biological response modifier, Cancer, Glioma, Glioblastoma Multiforme, Glioblastoma Multiforme, Gliomatosis cerebri, Vaccines, Vaccines, Neoplasms, Nerve Tissue, Germ cell tumor, neurectoderma |
|---|---|
| Age | 18-75 years |
| Treatment | Temozolomide, Dendritic Cell/Tumor Fusion Vaccine, Interleukin-12 |
| Clinical Study Identifier | NCT04388033 |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Last Modified on | 19 February 2024 |
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