Strain vs. Left Ventricular Ejection Fraction-based Cardiotoxicity Prevention in Breast Cancer
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- STATUS
- Recruiting
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- participants needed
- 136
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- sponsor
- Samsung Medical Center
Summary
Comparing preventive effect of myocardial global longitudinal strain-based cardioprotective stragety (angiotensin receptor blocker prophylaxis) with left ventricular ejection fraction-based strategy in breast cancer patients treated with adjuvant trastuzumab.
Description
Despite the left ventricular global longitudinal strain (GLS) enables early prediction of trastuzumab-related cardiomyopathy, its clinical application has been hampered due to the lack of appropriate evaluation and treatment strategies. Therefore, we aimed to evaluate the effect of early intervention strategy (GLS-based cardiotoxicity monitoring and administration of candesartan) by comparing with conventional intervention strategy (left ventricular ejection fraction-based cardiotoxicity monitoring and administration of candesartan) in breast cancer patients who treated with adjuvant trastuzumab.
Details
| Condition | prevention & control, Breast Cancer, Breast Cancer, Immunostimulant, Pharmaceutical Adjuvants, Breast Cancer - HER2 Positive, Chronic Shoulder Pain, Trastuzumab |
|---|---|
| Age | 18years - 100years |
| Treatment | Candesartan |
| Clinical Study Identifier | NCT04429633 |
| Sponsor | Samsung Medical Center |
| Last Modified on | 19 February 2024 |
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