The Efficacy of Adjuvant Chemotherapy in Locally Advanced Cervical Cancer
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- STATUS
- Recruiting
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- End date
- Apr 5, 2028
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- participants needed
- 120
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- sponsor
- Chongqing University Cancer Hospital
Summary
The aim of this trial was to evaluate the efficacy of adjuvant chemotherapy in the locally advanced cervical cancer with residual lesions after concurrent chemoradiation therapy.
Description
- Objective:
To compare response rate and survivals of locally advanced stage cervical cancer patients with residual lesions who had CCRT alone to those who had adjuvant chemotherapy after CCRT.
2. Patients:
- Cervical cancer stage IIb to IVa with a histopathology of squamous cell carcinoma, adenosquamous cell carcinoma, adenocarcinoma
- Complete CCRT(Radiation Does: A point 85Gy(+/-10%)B50Gy(+/-10%)concurrent paclitaxel and cisplatin once a week for six cycles)
- MRI is performed within 4 weeks after CCRT and shows residual lesions (non-lymph node10mmlymph node shortest diameter15mm).
- Methods:
The patients who have residual lesions after CCRT are randomized to arm A by observation or arm B by adjuvant chemotherapy with paclitaxel plus cisplatin every 3 weeks for 3 cycles.
Details
| Condition | Cervical Cancer, Cervical Cancer, Uterine Cancer, Uterine Cancer |
|---|---|
| Age | 18years - 75years |
| Treatment | CCRT, Paclitaxel, Cisplatin |
| Clinical Study Identifier | NCT04409860 |
| Sponsor | Chongqing University Cancer Hospital |
| Last Modified on | 19 February 2024 |
How to participate?
Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
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