Correlation of VEGF-A and Fluid Balance in Septic Shock

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    University Hospital, Rouen
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Updated on 19 February 2024
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shock
antibiotics
antibiotic therapy
vascular endothelial growth factor
sepsis
vasoconstrictor
septic shock
administration of intravenous fluids

Summary

VEGF is a key molecule in the control of vascular permeability via interactions with the VEGF-receptor on the endothelial cell. Several authors reported plasma VEGF levels are elevated in sepsis shock and associated with increased mortality (1,2).

In septic shock, the main elements of treatment are intravenous fluids, appropriate antibiotics and vasopressors. Some authors observed positive fluid balance is associated with increased mortality rates in patients (3,4).

To the best of our knowledge, no studies have shown a correlation between VEGF levels and the fluid balance. The aim of our study was to determine the role of VEGF in capillary leakage and the positive fluid balance in septic shock.

Details
Condition Toxic Shock Syndrome
Age 18years - 100years
Treatment Evaluation of VEGF-A levels in patients with septic shock is positively correlated with a positive fluid balance.
Clinical Study IdentifierNCT04474431
SponsorUniversity Hospital, Rouen
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patient above 18 years old
Patient with septic shock (presence of an infection, hypotension with mean arterial pressure less than 65mmHg and the need for vasopressor treatment (minimum dose 0,3/kg/min)
Person informed and signed consent

Exclusion Criteria

Death predicted within 24 hours
Limitation of therapeutic attitudes
Treatment with bevacizumab in the past 6 months
Pathologies with endothelial dysfunction (scleroderma, clarkson syndrome...)
Acute renal failure (KDIGO 3) at ICU admission defined by
Increase in serum creatinine to > 354mol/l or 3 times baseline OR
Urine output 0,3 ml/kg/h for 24h OR
Anuria for 12h
Morbid obesity with a body mass index (BMI) > 35 kg/m
Limb amputation
Morbid obesity with a body mass index (BMI) > 35 kg/m
Amputation of a limb
Pregnant or nursing women
Inability to obtain consent from family
Person with guardianship or curatorship
Clear my responses
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