Sympathoinhibition as a Preferred Second Line Treatment of Obesity Related Hypertension

STATUS

Recruiting
participants needed

120
sponsor

Royal Perth Hospital

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Updated on 19 February 2024

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body mass index

hypertension

amlodipine

ace inhibitor

amlodipine 5 mg

moxonidine

Summary

This study is designed to investigate whether sympathoinhibition with moxonidine could provide added metabolic benefit compared to the second line therapy in the current guidelines.

Description

This is a randomised, double-blind, cross-over study. Participants will be randomly assigned to receive either moxonidine 0.4mg daily or amlodipine 5mg and will later receive the alternate treatment.

Comprehensive testing will occur after each 12 week treatment phase and will include assessment of muscle sympathetic nerve activity, gut microbiome analysis and metabolic markers.

Details

Condition	Vascular Diseases, Vascular Diseases, Hypertension, Obesity, Obesity
Age	25-65 years
Treatment	Moxonidine 0.4 MG, Amlodipine 5mg
Clinical Study Identifier	NCT04474899
Sponsor	Royal Perth Hospital
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Age: 25 -65 years
	(Body Mass Index) BMI30kg/m2
	Currently weight stable (+/- 3% in previous 6-12 months and not on any specific exercise or dietary program)
	Elevated clinic systolic (Blood Pressure) BP 135 or diastolic BP 85mmHg
	on ACE inhibitor for at least 6 weeks prior to baseline assessment
Exclusion Criteria
	Grade 2-3 hypertension (systolic office BP >160, diastolic office BP >100 mmHg)
	Secondary causes of hypertension
	CKD (Chronic kidney disease) stage 4-5 {(estimated glomerular filtration) eGFR<30ml/min}
	Heart failure NYHA (New York Heart Association) class II-IV
	Recent CV (cardiovascular) event (acute myocardial infarction, acute coronary syndrome, stroke or transient ischaemic attack within the previous six months) unstable psychiatric condition
	medication such as corticosteroids, several antidepressants and antipsychotics
	Female participants of childbearing potential must have a negative pregnancy test prior to treatment

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Sympathoinhibition as a Preferred Second Line Treatment of Obesity Related Hypertension