Switch of Renin-Angiotensin System Inhibitors in Patients With Covid-19

  • STATUS
    Recruiting
  • participants needed
    240
  • sponsor
    University of Sao Paulo
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Updated on 19 February 2024
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hypertension
antihypertensive drugs
angiotensin
chest ct
serologic test

Summary

The SWITCH-COVID trial will randomize patients with COVID-19 that are currently using renin-angiotensin system inhibitors for treating hypertension to maintain the therapy during in-hospital stay or switch the therapy to other antihypertensive classes.

Description

Patients eligible for the study, after signing informed consent will be randomized 1:1 for maintenance of renin-angiotensin system inhibitors or switching the antihypertensive therapy for other classes according to a pre-specified protocol.

Patients are going to be followed during hospital stay for evaluation of clinical endpoints. Also blood and urine samples will be acquired for evaluation of renin-angiotensin system activation.

Details
Condition COVID19, Angiotensin II Receptor Antagonist Adverse Reaction
Age 18years - 80years
Treatment Renin-angiotensin system inhibitors
Clinical Study IdentifierNCT04493359
SponsorUniversity of Sao Paulo
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Hypertension in use of renin-angiotensin system inhibitors
Confirmed COVID-19 infection by rt-PCR, serology tests or typical clinical presentation and chest CT
Symptoms onset < 96h
Need for hospitalization

Exclusion Criteria

Heart failure
Previous cerebrovascular disease
Previous myocardial infarction
Blood pressure > 180 x 100 mmHg
Need for 3 or more anti-hypertensive classes
Use os spironolactone
Severe pulmonary disease
Contraindication for using other anti-hypertensive classes (calcium channel blockers, hydralazine, diuretics or nitrates)
Clear my responses
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