AMG 510 Ethnic Sensitivity Study (CodeBreak 105).

  • STATUS
    Recruiting
  • participants needed
    12
  • sponsor
    Amgen
Updated on 19 February 2024

Summary

To evaluate safety, tolerability, PK, and preliminary efficacy of AMG 510 PO QD in subjects of Chinese descent with KRAS p.G12C-mutant advanced/metastatic solid tumors.

Details
Condition Advanced/Metastatic Solid Tumors With KRAS p.G12C Mutation
Age 18-100 years
Treatment AMG 510
Clinical Study IdentifierNCT04380753
SponsorAmgen
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Male or female subjects greater than or equal to 18 years old
Subject is of Chinese ancestry
Pathologically documented, advanced/metastatic solid tumor with KRAS p.G12C mutation identified

Exclusion Criteria

Active brain metastases from non-brain tumors
Myocardial infarction within 6 months of study day 1
Gastrointestinal (GI) tract disease causing the inability to take oral medication
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