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HA-1H TCR T Cell for Relapsed/Persistent Hematologic Malignancies After Allogeneic Stem Cell Transplantation

Exploring new treatment for certain blood cancers after stem cell transplant.

Recruiting
18 years and older
All
Phase 1

Research Study for Blood Cancer Patients

This study is testing an investigational medication for patients with blood cancers that have come back or not gone away after a special type of stem cell transplant. The goal is to find the best dose for further studies. This treatment uses special cells called T cells from the patient, which are modified to help the body fight cancer. Patients will receive these cells through a single intravenous (IV) infusion.

  • **Study Length and Visits**: The study involves multiple visits, starting with 9 patients to test different doses, then 20 more patients to check for safety and early results.
  • **Eligibility**: Participants must be 18 or older, have certain genetic markers (HLA-A*02:01 positive and HA-1H positive), and have had a stem cell transplant over 100 days ago, among other criteria.
  • **Exclusions**: Participants cannot have certain infections, severe organ issues, or be on specific medications that suppress the immune system. Pregnant or nursing women, or those not using birth control, cannot join.

If you have blood cancer and think you might qualify, please discuss with your doctor to see if this research might be right for you. 🩺

Study details
    childhood ALL
    Multiple Myeloma
    Multiple Myeloma
    Preleukemia
    Acute myeloid leukemia
    Acute myeloid leukemia
    Myelosclerosis with myeloid metaplasia
    myelofibrosis
    Lymphoproliferative Disorder
    Lymphoma
    MYELOPROLIFERATIVE DISORDER
    MYELODYSPLASTIC SYNDROME
    Chronic myeloid leukemia
    Chronic myeloid leukemia
    myelofibrosis

NCT04464889

Medigene AG

19 February 2024

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